Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 109 Heft: 2 Seiten: 809-820.

We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection (...) of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The article examines the role and place of the Mystery within the structure of Mamleev’s metaphysics. The author of the article implicates the concept of “chaosmos’’, introduced by James Joyce in the experimental novel “Finnegans Wake”, to the Mamleev’s Universe. This leads to the transformation of the formula “chaos – osmosis – cosmos”, actualized by postmodern discourse, into the formula “Chaos – Osmosis – Cosmos”. Chaos here is Sacred Chaos, being one of the metaphysical manifestations of Eternal Russia. Osmosis appears (...) to be an antinomic Russian life, which combines the incompatible, and sets itself fundamentally impossible tasks. The Сosmos brings us to the tradition of Russian cosmism with its problem of microcosm and macrocosm conformity. The author of the article points out that the all-pervading and unifying element of Mamleev’s chaos is the Mystery. It is one of the five key metathemes of Mamleev’s oeuvre. The particularity of the Mystery is that it provides a link between other metathemes: utrism “I”, Death, the Abyss and Russia. In the plane of utrism “I” the Mystery is seen as the mystery of man. The Mystery is related to Death by the person’s interest of his own destiny and finiteness. The problem of overcoming death and the passion for eternal life are the central themes that concern almost all the heroes of Mamleev’s novels and short stories. For Mamleev they are the source of values aimed at the human need to achieve a higher “I”. The connection between the Mystery and the Abyss, as well as the connection between the Mystery and Russia are the strongest and the most important for Mamleev. Consideration of these connections prompts the author to conclude that Yuri Mamleev describes such dimensions of the Mystery, which go beyond the categories “unfathomable-to-us” and “unfathomable-in-itself”, introduced by S. Frank. This requires the introduction of new concepts that would bring out the essence of Mamleev’s innovations. The author of the article proposes to consider the Abyss as a “Last Mystery” by the fact it is transcendent to the transcendents themselves, that is it goes beyond the Absolute, as well as to consider Eternal Russia as a Russia-Mystery on the grounds that Mamleev gives it the status of the third metaphysical Beginning, along with the Absolute and the Abyss. (shrink)

This book is not only a major twentieth-century contribution to Dostoevsky’s studies, but also one of the most important theories of the novel produced in our century. As a modern reinterpretation of poetics, it bears comparison with Aristotle.“Bakhtin’s statement on the dialogical nature of artistic creation, and his differentiation of this from a history of monological commentary, is profoundly original and illuminating. This is a classic work on Dostoevsky and a statement of importance to critical theory.” Edward Wasiolek“Concentrating on the (...) particular features of ‘Dostoevskian discourse,’ how Dostoevsky structures a hero and a plot, and what it means to write dialogically, Bakhtin concludes with a major theoretical statement on dialogue as a category of language. One of the most important theories of the novel in this century.” The Bloomsbury Review. (shrink)

The article dealt with the question of the ratio of Yuri Mamleev’s I-utrism to Tradition. The problem is in the contradiction between two positions, which Mamleev notes in different places of “The Destiny of Being” – a view of the I-utrism as a new approach within the framework of Tradition, and as going beyond it with the introduction of extraneous elements. Based on the connection between the I-utrism and the “Last Doctrine”, which clearly lies outside the Tradition, the author of (...) the article concludes that the I-utrism should not be considered as a new approach within the framework of the Tradition, but as an autonomous construction to it. According to the author, the I-utrism due to its own radicalism contains two key problems that lead not only to a break with Tradition but also to a violation of the inner integrity of Mamleev’s philosophy itself. These two problems are defined as the radicalization of the Vedanta formula “Atman = Brahman” and the absence of the figure of the Other. I-utrism forms unified I, which the author of the article proposes to call “I-total”, because it displaces everything but itself, including the classical concept of the Absolute. Hence the lack of a topos for Mamleev’s concepts such as “Abyss” and “Eternal Russia”. It is compounded by the prevention of the metaphysical event of the Other, which is especially important for the idea of a metaphysical and mysterious Russia that requires intersubjectivity. In the process of analyzing these problems and issues, the article compares the philosophical positions of Stirner and Mamleev, as well as addresses the topic of demonic I-utrism. After all, the author concludes that the I-utrism needs to be revised and softened. This would allow it to exist organically in the overall picture of Mamleev’s worldview and not lose touch with Tradition despite the inevitable exit from it. (shrink)

The author of the article studies the creative legacy of Yuriy Mamleev, trying to establish the correlation between of his philosophical and fiction writings. The conventional editorial distinction between philosophical and literary texts as different and autonomous categories is rejected. Instead of the idea, that philosophical and fictional aspects of texts by Mamleev are inextricably linked, it is claimed that they should be considered together. In the author’s opinion, these texts present different perspectives and implementations of his oeuvre that contains (...) the rational dimension and on the other hand – irrational dimension of artistic images and obscure allusions. Mamleev’s writings considered by means of 5 crucial “metathemes”: Аbyss and the “Ultimate relationships” concerned with it, the Mystery which has two levels – one cognizable and the another – uncoognizable in principal, the “root of self-being” and metaphysic of “I”, death and immortality, Russia and the Russian soul which are existed between West and East with special historical and cosmological mission. It is concluded that these 5 metathemes pervade all Mamleev’s texts and comprise his spiritual search. The characters of Mamleev’s fiction are mostly people of post-Soviet world, who ask questions with no set answers to become acquainted with the secrets of being. At the same time they are concerned with their own existence, their self destiny. Their actions are extraordinary and illogical. Supposedly Mamleev’s artistic images not only correspond with his philosophical ideas, for instance – utrism or the “Ultimate relationships”, but also reveal them from unexpected perspective. The author determines that distinction between philosophy and literature of Mamleev is incorrect, as these areas are conflated. Any distinction of this kind will ruin the logic of Mamleev’s thinking and outlook. Thus, metaphysical realism can be viewed as the crossing, distinction blurring area, productive and creative transgression. Or as the situation when philosophy is more than it is itself. (shrink)

The article is devoted to the problem of the naming crisis of modern society. The sequences by which the social and cultural history of the West is ordered, represented by the evolution of economics, technology, religion, forms of capital and wealth, communications, following the technological acceleration of time, coexist with each other, compete for primacy, creating a society of atomized subjects who have ceased to understand their place in the history of society. This situation is described in the article as (...) an identity crisis. The purpose of this work is to demonstrate the gaps that have been discovered in attempts to identify society, which are the object of criticism. The article refers to the tradition of explanatory modeling of social interactions in terms of psychopathology and psychiatry. The crisis of the identity of society is illustrated through the images of madness in modern art culture. The article hypothesizes that there is an unspoken ban on naming a society associated with the crisis of capitalism in the transition from disciplinary societies to control societies. Culture's interest in insanity serves as an indicator of a social crisis. The evolution of cultural interest in the figure of a madman from a frightening "outcast" to an attractive "rebel" is shown. The article suggests the tasks of critical philosophy that coincide with the tasks of caring for social health. The idea of the need for the deprivation of mental illness is expressed. Mental health care is considered as a social task. (shrink)

The article discusses the importance of strength training in the training process and its impact on the technical skills of athletes. The use of strength exercises during training sessions and rational planning of strength training in the training process are considered. Practical and methodological recommendations are given on the use of various strength physical exercises to improve the technique of basic competitive movements. Examples of the use of various physical loads during certain exercises in order to improve the technical readiness (...) of athletes are shown. (shrink)

In the existing philosophical interpretations of mystical experience (constructivism, essentialism, etc.), its essence is usually seen in the features of "mystical knowledge". At the same time, the value-semantic foundations of mystical experience and its existential aspect remain in the shadows. In this article, the mystical experience is analyzed from the standpoint of the theories of the subject's objective activity - the theory of activity (developed in Russian psychology), enactivism, and the concept of the "life world". It is shown that the (...) essence of mystical experience is manifested not in cognitive, but in value-semantic, existential attitude to the world, which is represented by two groups of value-semantic viewpoints. In the first, the dependence of the subject on the sacred object of mystical experience is expressed, in the second - the volitional focus of the subject on overcoming such dependence, "mastering", "acquiring" the sacred object. These attitudes reflect the duality of the need-motivational sphere of consciousness, which gives the activity of the subject, on the one hand, activity, energy, and on the other, meaning. In mystical experience, the subject of active "development", "acquisition" (which can be both real and virtual) is an imaginative "otherworldly reality". The analysis allows us to conclude that mystical experience is one of the forms of motivational states of consciousness. Its peculiarity is that it is aimed at realizing the need for the harmonization of the subject's relations with the natural and social environment, the subject's finding the meaning of the "existence of his self" in an always open to the future, incomplete life world. It is the motivational basis that gives the mystical experience an improvisational character, as well as a creative, renewing potential (within the boundaries of the sensory-emotional experience of the world by the subject). The article also analyzes the concept of semantic reality. It is shown that the semantic foundations of mystical experience reflect the individually unique aspects of human life, are the result of the interactions of many factors of socio-cultural, individual-personal nature (psychological, medical, pharmacological, gender, psychiatric, etc.). (shrink)

The article examines some aspects of Brentano's ontology, starting with his 1862 dissertation "On the ambiguity of Being according to Aristotle", as well as its influence on the philosophy of M. Heidegger. The author shows that the ontology of the early Brentano is not limited to ousiology, since it includes a discussion of the field of mental being (ens rationis, ὂν ὡς ἀληθές) and it is in this aspect that he influences the young Heidegger. Following Aristotle, Brentano assigns a central (...) role to the ontology of essence, which in the late period leads him to the position of reism, but in the lectures of the middle period Brentano discusses the problems of intentional inexistence, thanks to which projects of "new types of ontology" by Husserl and Mainong appear. The author believes that Heidegger was also influenced by these ideas. Of course, there are fundamental differences between the positions of Brentano and Heidegger, but the similarities are quite large. In particular, if Brentano, highlighting the real and true areas, gives preference in favor of the former, then Heidegger's ontology is built on the second member of this opposition. In particular, everything that can be given is called being by Heidegger, because we are talking about intentional being, about ens rationis, or ὂν ὡς ἀληθές. (shrink)

The article deals with Heidegger’s interpretation of antique ontology, in which Being was conceptualized in terms of production. What is this interpretation and why is it so important? Until recently, it has been difficult to answer these questions, since the texts in question have only in recent years become publicly available, and therefore have not yet been fully absorbed in Heideggerian-studies. Consequently, even the very useful works that cover the subject of production-theme in Heidegger focus more on the question of (...) technique and do not consider the formation of this problematic, and therefore do not deal with it substantively. In the years 1921-1924, Heidegger was closely involved with Aristotle and lectured on his favorite philosopher for four years. It was during this period that he began to interpret Being in Aristotle as being-made, being-produced (das Hergestelltsein), and then extended this interpretation to the whole of ancient and medieval philosophy. This is a very remarkable moment in terms of methodology that characterizes Heidegger as a historian of philosophy. In this article, the author examines Heidegger’s interpretation of ancient ontology, revealing its weaknesses. (shrink)

We apply Benacerraf’s distinction between mathematical ontology and mathematical practice to examine contrasting interpretations of infinitesimal mathematics of the seventeenth and eighteenth century, in the work of Bos, Ferraro, Laugwitz, and others. We detect Weierstrass’s ghost behind some of the received historiography on Euler’s infinitesimal mathematics, as when Ferraro proposes to understand Euler in terms of a Weierstrassian notion of limit and Fraser declares classical analysis to be a “primary point of reference for understanding the eighteenth-century theories.” Meanwhile, scholars like (...) Bos and Laugwitz seek to explore Eulerian methodology, practice, and procedures in a way more faithful to Euler’s own. Euler’s use of infinite integers and the associated infinite products are analyzed in the context of his infinite product decomposition for the sine function. Euler’s principle of cancellation is compared to the Leibnizian transcendental law of homogeneity. The Leibnizian law of continuity similarly finds echoes in Euler. We argue that Ferraro’s assumption that Euler worked with a classical notion of quantity is symptomatic of a post-Weierstrassian placement of Euler in the Archimedean track for the development of analysis, as well as a blurring of the distinction between the dual tracks noted by Bos. Interpreting Euler in an Archimedean conceptual framework obscures important aspects of Euler’s work. Such a framework is profitably replaced by a syntactically more versatile modern infinitesimal framework that provides better proxies for his inferential moves. (shrink)